Pyridine → HCID 21693441, compound

HRID 1590849Notes

Reaction equation

HRID 1590849 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][N:16]=2)=[C:11]([F:22])[CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].N1C=CC=CC=1.[C:29](Cl)(=[O:38])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][C:29](=[O:38])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])=[CH:17][N:16]=2)=[C:11]([F:22])[CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 3

HCID 1049PyridineHCID 69819Nonanoyl chlorideHCID 19768419HCID 19768419, compound

Product 1

HCID 21693441HCID 21693441, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.1 mol of 2-(4-heptyloxy-2-fluorophenyl)-5-hydroxypyridine (prepared from 4-heptyloxy-2-fluoroacetophenone in accordance with Example 1) is dissolved together with 0.12 mol of pyridine in toluene and 0.1 mol of nonanoyl chloride is then added at room temperature. Stirring is then carried out for 12 hours and standard working-up is carried out. 2-(4-Heptyloxy-2-fluorophenyl)5-nonanoyloxypyridine is obtained.

Workup

  1. additionis then added at room temperature

Sources & evidence

ORD record
ord-63411109f2dd4d288f46afe2450881eb
Source dataset
uspto-grants-1993_04
Patent number
US05204476

Reaction notes

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