HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl lactate → 2-(4-Octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl lactate | HCID 98054 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 2-(4-Octyloxy-2-fluorophenyl)-5-hydroxypyridine | HCID 22717460 | — |
| Product | 2-(4-Octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine | HCID 19768414 | — |
Reaction Steps
Optically active benzyl lactate is etherified by means of diethyl azodicarboxylate (DEAD)/triphenylphosphine with 2-(4-octyloxy-2-fluorophenyl)-5-hydroxypyridine (prepared in accordance with Example 1) and the benzyl group is then split off hydrogenolytically. The acid so obtained is converted as usual into the nitrile (oxalyl chloride, ammonia, thionyl chloride). Optically active 2-(4-octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05204476 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-c13875652fd042b99e09cb22bf04964e |
| Source note | uspto-grants-1993_04 |