3-hydroxy-4-nitro-3H-isobenzofuran-1-one → 4-Amino-3-hydroxyphthalide

Participants

Reaction Steps

10 g of 3-hydroxy-4-nitro-phthalide are dissolved in 100 ml of tetrahydrofuran and hydrogenated at atmospheric pressure and at 20-35° C. after adding 1 g of palladium on barium sulphate (5%). The catalyst is filtered off and the filtrate is concentrated. The evaporation residue is stirred with ether and filtered with suction. 5.8 g (68.5% of theory) of a colorless substance of melting point 280-285° C. (dec.) are obtained.

Provenance & Evidence