HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-phenyl-1,3-thiazole-4-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 5-phenylthiazole-4-carboxylate | HCID 12300673 | — |
| Product | 5-phenyl-1,3-thiazole-4-carboxylic Acid | HCID 944813 | 72% |
Reaction Steps
The ethyl 5-phenylthiazole-4-carboxylate was hydrolyzed according to known methods with 2 N aqueous sodium hydroxide solution at 70° for 30 minutes, whereby, after acidification, there was obtained in 72% yield 5-phenyl-4-thiazolecarboxylic acid which melted at 189°-190° after recrystallization from methanol/diethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05204482 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-0f8c614fb04a4b2289cbb407146430c3 |
| Source note | uspto-grants-1993_04 |