Ethyl isocyanoacetate → HCID 19768833, compound

HRID 1590879Notes

Reaction equation

HRID 1590879 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12](OC)=[S:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:19]([CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])#[C-:20]>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:12]2[S:13][CH:20]=[N:19][C:21]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:16]=[CH:17][CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 533707Ethyl isocyanoacetateHCID 19768715HCID 19768715, compound

Product 1

HCID 19768833HCID 19768833, compoundYield 92.9%

Procedure

In an analogous manner to that described in Example 1(C), 21.7 g of O-methyl 3-(benzyloxy)thiobenzoate (44.13 mmol) were reacted with ethyl isocyanoacetate, whereby there were obtained 26.5 g (92.9%) of ethyl 5-[3-(benzyloxy)phenyl]-4-thiazolecarboxylate as an orange oil.

Sources & evidence

ORD record
ord-244dba93124043968db7b417cac7a71d
Source dataset
uspto-grants-1993_04
Patent number
US05204482

Reaction notes

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