Dichloromethane → HCID 19768651, compound

Participants

Reaction Steps

1.46 g (4.2 mmol) of t-butyl [2-(2-amino-5-phenyl-4-oxazolecarboxamido)ethyl]carbamate were dissolved in 50 ml of methylene chloride and treated with 5 ml of trifluoroacetic acid. The reaction mixture was heated to reflux while stirring for 2.5 hours and thereafter evaporated under reduced pressure. The residue was dissolved in methanol, treated with 5 ml of 2 M methanolic hydrochloric acid and evaporated. Recrystallization of the residue from methanol/diethyl ether yielded 1.3 g (94%) of 2-amino-N-(2-aminoethyl)-5-phenyl-4-oxazolecarboxamide dihydrochloride as white crystals, melting point 260°.

Provenance & Evidence