Dichloromethane → HCID 19768594, compound

Participants

Reaction Steps

1.5 g (4.33 mmol) of t-butyl [2-(5-amino-4-phenyl-3-isoxazolecarboxamido)ethyl]carbamate in 5 ml of methylene chloride were stirred at room temperature for 16 hours with 1.7 ml of trifluoroacetic acid. Thereafter, the reaction mixture was evaporated under reduced pressure; the residue was dissolved in ethanol, whereupon the solution was treated with 2 ml of ethanolic hydrochloric acid (17.5% w/v) and again evaporated. Recrystallization of the residue from methanol/ether yielded 0.9 g (73.5%) of 5-amino-N-(2-aminoethyl)-4-phenyl-3-isoxazolecarboxamide hydrochloride as white crystals, melting point 187°-189°.

Provenance & Evidence