HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → Ethyl 3-cyano-3-phenylpyruvate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | Phenylacetonitrile | HCID 8794 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Product | Ethyl 3-cyano-3-phenylpyruvate | HCID 22845 | 90% |
Reaction Steps
Reaction of benzyl cyanide, sodium ethylate and diethyl oxalate according to the method described in Org. Synth. Coll. Vol. II (1943) 287 and Chem. Ber. 107 (1974) 2974-2795 in alcohol, acidification with conc. (37%) hydrochloric acid to pH 2 and subsequent recrystallization of the separated precipitate from ethanol yielded ethyl phenylcyanopyruvate in 90% yield as yellow crystals, melting point 127°-128°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05204482 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-2957a0910e87485f964d48039a7ed007 |
| Source note | uspto-grants-1993_04 |