N-BOC-ethylenediamine → HCID 178453699, compound

Participants

Reaction Steps

4.6 g (19.64 mmol) of ethyl 4-(3-fluorophenyl)-3-pyrazolecarboxylate were reacted with t-butyl (2-aminoethyl)carbamate in an analogous manner to that described in Example 16. Chromatography of the crude product and recrystallization from ethyl acetate/hexane yielded 4.4 g (64.6%) of t-butyl [2-(4-(3-fluorophenyl)-3-pyrazolecarboxamido)ethyl]carbamate as white crystals, melting point 175°-176°.

Provenance & Evidence