HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 19768527 | HCID 19768527 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(4-fluorophenyl)-1-methyl-1H-pyrazole-3-carboxylic acid | HCID 19768648 | 90.6% |
Reaction Steps
8.6 g (34.6 mmol) of ethyl 4-(4-fluorophenyl)-1-methyl-3-pyrazolecarboxylate were heated to 70° for 60 minutes with 90 ml of 2N sodium hydroxide solution and 50 ml of water. Conversion into the acid form and recrystallization of the crude product from ethyl acetate/hexane yielded 6.9 g (90.4%) of 4-(4-fluorophenyl)-1-methyl-3-pyrazolecarboxylic acid as white crystals, melting point 146°-147°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05204482 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-501fe2e1066c425b91c71d489aca44f5 |
| Source note | uspto-grants-1993_04 |