HCID 19768791, compound → HCID 19768569, compound

HRID 1590902Notes

Reaction equation

HRID 1590902 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[S:13][CH:12]=[N:11][C:10]=2[C:14]([O:16]CC)=[O:15])[CH:5]=[C:6]([F:8])[CH:7]=1>O>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[S:13][CH:12]=[N:11][C:10]=2[C:14]([OH:16])=[O:15])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 1

HCID 19768791HCID 19768791, compound

Product 1

HCID 19768569HCID 19768569, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The ethyl 5-(3,5-difluorophenyl)-4-thiazolecarboxylate was saponified in an analogous manner to that described in Example 1(D), whereby after acidification there was obtained 5-(3,5-difluorophenyl)-4-thiazolecarboxylic acid in 97% yield, melting point 200° (from water).

Sources & evidence

ORD record
ord-5859e6a746cb41678f83236bccf38823
Source dataset
uspto-grants-1993_04
Patent number
US05204482

Reaction notes

Loading…