HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2,6-Dichloro-5-fluoronicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2,6-Dichloro-5-fluoro-3-pyridinecarbonyl chloride | HCID 2733666 | — |
| Reactant | Lithium | HCID 3028194 | — |
| Product | 2,6-Dichloro-5-fluoronicotinic acid | HCID 2733659 | — |
Reaction Steps
An improved process for the preparation of 2,6-dichloro-5-fluoronicotinoyl chloride is described where a 2,6-dihydroxy-5-fluoronicotinic acid ester is converted in one step using phosphorus oxychloride and a lithium reagent to 2,6-dichloro-5-fluoronicotinoyl chloride and subsequent basic hydrolysis affords 2,6-dichloro-5-fluoronicotinic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05204478 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-0abbec808d7748bcac7d4a57eb1dbe36 |
| Source note | uspto-grants-1993_04 |