HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Acetamido-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine → 4-Amino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Acetamido-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine | HCID 23372120 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Amino-1-cyclohexyloxy-2,2,6,6-tetramethylpiperidine | HCID 22277984 | — |
Reaction Steps
A solution of 5.0 g of the acetamide from Example 47 in 7.5 ml of water and 7.5 ml of conc. hydrochloric acid is heated at reflux for 10 hours. The reaction mixture is then quenched with saturated sodium carbonate and extracted with ethyl acetate. The combined organic extracts are washed with water, brine, dried (MgSO4) and evaporated to leave a light brown oil. Distillation (Kugelrohr, 140° C. @ 1.5 mm) affords the title compound as a clear colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05204473 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-20400bae19bc435083a1307f1c5118eb |
| Source note | uspto-grants-1993_04 |