Sodium Hydroxide → HCID 19768383, compound

Participants

Reaction Conditions

Reaction Steps

4-n-Butylamino-2,2,6,6-tetramethylpiperidine (31.7 g, 149 mmol) is added over 15 minutes to a suspension of 15.0 g (67.8 mmol) of the 2,4-dichloro-6-diethylamino-1,3,5-triazine, 150 ml of xylene, and 7.0 g of powdered sodium hydroxide that had been heated to 70° C. The reaction mixture is heated at reflux for 23 hours. Sodium chloride is removed by filtration, and the filtrate is concentrated to a viscous oil. Further concentration of the oil by Kugelrohr distillation (140°-50° C., 0.05 mm) yields a residue which is crystallized from methanol-water to afford 25.8 g (66% yield) of 2,4-bis[N-(2,2,6,6-tetramethylpiperidin-4-yl)-n-butylamino]-6-diethylamino-1,3,5-triazine, m.p. 74°-76° C.

Provenance & Evidence