HCID 13917964, compound → HCID 131717865, compound

HRID 1590969Notes

Reaction equation

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:12]([NH:14][CH2:15][C:16]([NH:18][C@H:19]([C:30]([N:32]1[CH2:39][CH2:38][CH2:37][C@H:33]1[C:34]([NH2:36])=[O:35])=[O:31])[C@@H:20]([CH3:29])[O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:17])=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH:47]([C:66]([O:68][C:69]([CH3:72])([CH3:71])[CH3:70])=[O:67])[C@H:48]([C:59]([NH:61][CH2:62][C:63]([OH:65])=O)=[O:60])[C@@H:49]([CH3:58])[O:50][CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1>>[NH:47]([C:66]([O:68][C:69]([CH3:72])([CH3:71])[CH3:70])=[O:67])[C@H:48]([C:59]([NH:61][CH2:62][C:63]([NH:1][C@H:2]([C:12]([NH:14][CH2:15][C:16]([NH:18][C@H:19]([C:30]([N:32]1[CH2:39][CH2:38][CH2:37][C@H:33]1[C:34]([NH2:36])=[O:35])=[O:31])[C@@H:20]([CH3:29])[O:21][CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:17])=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:65])=[O:60])[C@@H:49]([CH3:58])[O:50][CH2:51][C:52]1[CH:53]=[CH:54][CH:55]=[CH:56][CH:57]=1

Participants

Reactant 2

HCID 13917964HCID 13917964, compound

HCID 131717866Boc-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2

Product 1

HCID 131717865HCID 131717865, compoundYield 77.7%

Procedure

By using 30.00 g of Boc-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2 and 19.60 g of Boc-Thr(Bzl)-Gly-OH, and the same procedure as in Reference Example 15 was repeated to obtain 32.36 g (yield: 77.7%) of the above-mentioned objective product.

Sources & evidence

ORD record: ord-c8ec67a7971445c59f7a5a801c13f078
Source dataset: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05204326

Reaction notes

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