Boc-Thr(Bzl)-OSu → HCID 131717867, compound
Reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:21]([NH:23][CH2:24][C:25]([NH:27][C@H:28]([C:38]([NH:40][CH2:41][C:42]([NH:44][C@H:45]([C:56]([N:58]1[CH2:65][CH2:64][CH2:63][C@H:59]1[C:60]([NH2:62])=[O:61])=[O:57])[C@@H:46]([CH3:55])[O:47][CH2:48][C:49]1[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1)=[O:43])=[O:39])[CH2:29][O:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:26])=[O:22])[C@@H:11]([CH3:20])[O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:8])[CH2:3][C:4](=[O:6])[NH2:5].[NH:73]([C:95]([O:97][C:98]([CH3:101])([CH3:100])[CH3:99])=[O:96])[C@H:74]([C:85]([O:87]N1C(=O)CCC1=O)=O)[C@@H:75]([CH3:84])[O:76][CH2:77][C:78]1[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=1>>[NH:73]([C:95]([O:97][C:98]([CH3:99])([CH3:100])[CH3:101])=[O:96])[C@H:74]([C:85]([NH:1][C@H:2]([C:7]([NH:9][C@H:10]([C:21]([NH:23][CH2:24][C:25]([NH:27][C@H:28]([C:38]([NH:40][CH2:41][C:42]([NH:44][C@H:45]([C:56]([N:58]1[CH2:65][CH2:64][CH2:63][C@H:59]1[C:60]([NH2:62])=[O:61])=[O:57])[C@@H:46]([CH3:55])[O:47][CH2:48][C:49]1[CH:50]=[CH:51][CH:52]=[CH:53][CH:54]=1)=[O:43])=[O:39])[CH2:29][O:30][CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)=[O:26])=[O:22])[C@@H:11]([CH3:20])[O:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:8])[CH2:3][C:4](=[O:6])[NH2:5])=[O:87])[C@@H:75]([CH3:84])[O:76][CH2:77][C:78]1[CH:79]=[CH:80][CH:81]=[CH:82][CH:83]=1Participants
3
Procedure
By using 21.00 g of Boc-Asn-Thr(Bzl)-Gly-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2 and 9.37 g of Boc-Thr(Bzl)-OSu, and the same procedure as in Reference Example 18 was repeated to obtain 23.4 g (yield: 93.6%) of the above-mentioned objective product. Melting point: 110-113° C.
Sources & evidence
- ORD record
- ord-97b02fee02224ea9bb71d6caca9b756f
- Source dataset
- uspto-grants-1993_04
- Patent number
- US05204326
Reaction notes
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