L-Ornithine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[imino[[(4-methylphenyl)sulfonyl]amino]methyl]- → Boc-Arg(Tos)-Thr(Bzl)-Asn-Thr(Bzl)-Gly-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2

Participants

Role	Name	HCID	Charge
Reactant	L-Ornithine, N2-[(1,1-dimethylethoxy)carbonyl]-N5-[imino[[(4-methylphenyl)sulfonyl]amino]methyl]-	HCID 83767	—
Reactant	HCID 131717867	HCID 131717867	—
Product	Boc-Arg(Tos)-Thr(Bzl)-Asn-Thr(Bzl)-Gly-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2	HCID 178427597	72.2%

Reaction Steps

By using 8.35 g of Boc-Thr(Bzl)-Asn-Thr(Bzl)-Gly-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2 and 3.30 g of Boc-Arg(Tos)-OH, and the same procedure as in Reference 15 was repeated to obtain 7.60 g (yield: 70.5%) of the above-mentioned objective product. Melting point: 120°-132° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05204326
Source dataset	uspto-grants-1993_04
ORD ID	ord-6d19f28a60d2416ab2b0d13522c53042
Source note	uspto-grants-1993_04