HCID 14131989, compound → HCID 15928432, compound

HRID 1590974Notes

Reaction equation

[NH:1]([C:23]([O:25]C(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:20]([OH:22])=[O:21])[CH2:11][O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[NH:30]([C:58]([O:60][C:61]([CH3:64])([CH3:63])[CH3:62])=[O:59])[C@H:31](C(ON1C(=O)CCC1=O)=O)[CH2:32][CH2:33][CH2:34][CH2:35][NH:36][C:37]([O:39][CH2:40][C:41]1[CH:47]=[CH:46][CH:45]=[CH:44][C:42]=1[Cl:43])=[O:38]>>[NH:30]([C:58]([O:60][C:61]([CH3:64])([CH3:63])[CH3:62])=[O:59])[C@H:31]([C:23]([NH:1][C@H:2]([C:7]([NH:9][C@H:10]([C:20]([OH:22])=[O:21])[CH2:11][O:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6])=[O:25])[CH2:32][CH2:33][CH2:34][CH2:35][NH:36][C:37]([O:39][CH2:40][C:41]1[CH:47]=[CH:46][CH:45]=[CH:44][C:42]=1[Cl:43])=[O:38]

Participants

Reactant 2

HCID 14131989HCID 14131989, compound

HCID 15003967N-(tert-Butoxycarbonyl)-L-leucyl-O-benzyl-L-serine

Product 1

HCID 15928432HCID 15928432, compoundYield 64%

Procedure

By using 4,61 g of Boc-Leu-Ser(Bzl)-OH Japanese Patent Kokai (Laid-open) No. 61-112099 (1986) and 5.61 g of Boc-Lys(Cl-Z)-OSu, and the same procedure as in Reference Example 31 was repeated to obtain 4.92 g (yield: 64.0%) of the above-mentioned objective product.

Sources & evidence

ORD record: ord-c525d4ca154d47efbaea9d687e786bf7
Source dataset: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05204326

Reaction notes

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