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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1590976Generated: October 25, 2026

L-Glutamine, N2-[(1,1-dimethylethoxy)carbonyl]-, 4-nitrophenyl ester → Boc-Gln-Thr(Bzl)-Pro-Gln-Thr(Bzl)-Asn-Thr(Bzl)-Gly-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2

https://huagongshe.com/reaction/1590976

Reaction equation

Participants

RoleNameHCIDCharge
ReactantL-Glutamine, N2-[(1,1-dimethylethoxy)carbonyl]-, 4-nitrophenyl esterHCID 7017891—
ReactantBoc-Thr(Bzl)-Pro-Gln-Thr(Bzl)-Asn-Thr(Bzl)-Gly-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2HCID 131717871—
ProductBoc-Gln-Thr(Bzl)-Pro-Gln-Thr(Bzl)-Asn-Thr(Bzl)-Gly-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2HCID 13171787095.8%

Reaction Steps

By using 2.65 g of Boc-Thr(Bzl)-Pro-Gln-Thr(Bzl)-Asn-Thr(Bzl)-Gly-Ser(Bzl)-Gly-Thr(Bzl)-Pro-NH2 and 907 mg of Boc-Gln-ONp, and the same procedure as in Reference Example 18 was repeated to obtain 2.74 g (yield: 95.5%) of the above-mentioned objective product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05204326
Source datasetuspto-grants-1993_04
ORD IDord-ca8783c8349c4305a126204db8de4502
Source noteuspto-grants-1993_04