HCID 15003988, compound → HCID 15003989, compound

HRID 1590981Notes

Reaction equation

HRID 1590981 reaction equation
N(C(OC(C)(C)C)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:26]([NH:28][C@H:29]([C:42]([O:44][CH3:45])=[O:43])[CH2:30][C:31]1[CH:36]=[CH:35][C:34]([O:37][CH2:38][C:39]([OH:41])=[O:40])=[CH:33][CH:32]=1)=[O:27])[C@@H:16]([CH3:25])[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH:53]([C:84]([O:86][C:87]([CH3:90])([CH3:89])[CH3:88])=[O:85])[C@H:54]([C:64]([NH:66][C@H:67]([C:72]([NH:74][C@H:75]([C:80]([NH:82]N)=[O:81])[CH2:76][CH:77]([CH3:79])[CH3:78])=[O:73])[CH2:68][C:69](=[O:71])[NH2:70])=[O:65])[CH2:55][O:56][CH2:57][C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=1>>[NH:53]([C:84]([O:86][C:87]([CH3:90])([CH3:89])[CH3:88])=[O:85])[C@H:54]([C:64]([NH:66][C@H:67]([C:72]([NH:74][C@H:75]([C:80]([NH:82][C@H:2]([C:12]([NH:14][C@H:15]([C:26]([NH:28][C@H:29]([C:42]([O:44][CH3:45])=[O:43])[CH2:30][C:31]1[CH:32]=[CH:33][C:34]([O:37][CH2:38][C:39]([OH:41])=[O:40])=[CH:35][CH:36]=1)=[O:27])[C@@H:16]([CH3:25])[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:81])[CH2:76][CH:77]([CH3:79])[CH3:78])=[O:73])[CH2:68][C:69](=[O:71])[NH2:70])=[O:65])[CH2:55][O:56][CH2:57][C:58]1[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=1

Participants

3

Reactant 2

HCID 15003988HCID 15003988, compoundHCID 131717873HCID 131717873, compound

Product 1

HCID 15003989HCID 15003989, compoundYield 63.8%

Procedure

By using 2.50 g of Boc-Ser(Bzl)-Thr(Bzl)-Tyr(CH2COOH)-OCH3 and 2.23 g of Boc-Ser(Bzl)-Asn-Leu-NHNH2 and the same procedure as in Reference Example 7 was repeated to obtain 2.49 g (yield: 63.8%) of the above-mentioned objective product.

Sources & evidence

ORD record
ord-c50dc14ea9e24308ab4f4a651c688455
Source dataset
uspto-grants-1993_04
Patent number
US05204326

Reaction notes

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