HCID 15003931, compound → HCID 15003963, compound

HRID 1590983Notes

Reaction equation

N(C(OC(C)(C)C)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:26]([NH:28][C@H:29]([C:42]([O:44][CH3:45])=[O:43])[CH2:30][CH2:31][CH2:32][CH2:33][NH:34][C:35]([CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:36])=[O:27])[C@@H:16]([CH3:25])[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH:53]([C:71]([O:73][C:74]([CH3:77])([CH3:76])[CH3:75])=[O:72])[C@H:54]([C:59]([NH:61][C@H:62]([C:67]([NH:69]N)=[O:68])[CH2:63][CH:64]([CH3:66])[CH3:65])=[O:60])[CH2:55][C:56](=[O:58])[NH2:57]>>[NH:53]([C:71]([O:73][C:74]([CH3:77])([CH3:76])[CH3:75])=[O:72])[C@H:54]([C:59]([NH:61][C@H:62]([C:67]([NH:69][C@H:2]([C:12]([NH:14][C@H:15]([C:26]([NH:28][C@H:29]([C:42]([O:44][CH3:45])=[O:43])[CH2:30][CH2:31][CH2:32][CH2:33][NH:34][C:35]([CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:36])=[O:27])[C@@H:16]([CH3:25])[O:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:68])[CH2:63][CH:64]([CH3:66])[CH3:65])=[O:60])[CH2:55][C:56](=[O:58])[NH2:57]

Participants

Reactant 2

HCID 15003931HCID 15003931, compound

HCID 15003962HCID 15003962, compound

Product 1

HCID 15003963HCID 15003963, compoundYield 71.4%

Procedure

By using 3.60 g of Boc-Ser(Bzl)-Thr(Bzl)-Lys(CO-CH2CH2COOH)-OCH3 and 2.21 g of Boc-Asn-Leu-NHNH2, and the same procedure as in Reference Example 7 was repeated to obtain 3.37 g (yield: 71.4%) of the above-mentioned objective product.

Sources & evidence

ORD record: ord-faaabdff630947609b705ab3a32ede26
Source dataset: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05204326

Reaction notes

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