tert-Butoxycarbonyl-L-isoleucine → HCID 15928434, compound

HRID 1590986Notes

Reaction equation

HRID 1590986 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[NH:23]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[C@H:24]([C:29]([OH:31])=O)[C@H:25]([CH2:27][CH3:28])[CH3:26]>>[NH:23]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[C@H:24]([C:29]([NH:1][C@H:2]([C:7]([NH:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6])=[O:31])[C@H:25]([CH2:27][CH3:28])[CH3:26]

Participants

3

Reactant 2

HCID 2724762tert-Butoxycarbonyl-L-isoleucineHCID 10041457HCID 10041457, compound

Product 1

HCID 15928434HCID 15928434, compoundYield 73.3%

Procedure

By using 2.00 g of Boc-Leu-Gly-OEt and 1.67 g of Boc-Ile-OH.1/2H2O and the same procedure as in Reference Example 15 was repeated to obtain 1.99 g (yield: 73.3%) of the above-mentioned objective product.

Sources & evidence

ORD record
ord-67ade5435996433099f930271eee0f73
Source dataset
uspto-grants-1993_04
Patent number
US05204326

Reaction notes

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