HCID 15003890, compound → HCID 131717878, compound

HRID 1590991Notes

Reaction equation

N(C(OC(C)(C)C)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:26]([NH:28][C@H:29]([C:35]([O:37][CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)=[O:36])[CH2:30][CH2:31][C:32](=[O:34])[OH:33])=[O:27])[C@@H:16]([CH3:25])[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH:52]([C:84]([O:86][C:87]([CH3:90])([CH3:89])[CH3:88])=[O:85])[CH2:53][C:54]([NH:56][C@H:57]([C:59]([NH:61][C@H:62]([C:72]([NH:74][C@H:75]([C:80]([NH:82]N)=[O:81])[CH2:76][CH:77]([CH3:79])[CH3:78])=[O:73])[CH2:63][O:64][CH2:65][C:66]1[CH:71]=[CH:70][CH:69]=[CH:68][CH:67]=1)=[O:60])[CH3:58])=[O:55]>>[NH:52]([C:84]([O:86][C:87]([CH3:90])([CH3:89])[CH3:88])=[O:85])[CH2:53][C:54]([NH:56][C@H:57]([C:59]([NH:61][C@H:62]([C:72]([NH:74][C@H:75]([C:80]([NH:82][C@H:2]([C:12]([NH:14][C@H:15]([C:26]([NH:28][C@H:29]([C:35]([O:37][CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)=[O:36])[CH2:30][CH2:31][C:32](=[O:33])[OH:34])=[O:27])[C@@H:16]([CH3:25])[O:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:81])[CH2:76][CH:77]([CH3:79])[CH3:78])=[O:73])[CH2:63][O:64][CH2:65][C:66]1[CH:71]=[CH:70][CH:69]=[CH:68][CH:67]=1)=[O:60])[CH3:58])=[O:55]

Participants

Reactant 2

HCID 15003890HCID 15003890, compound

HCID 131717879HCID 131717879, compound

Product 1

HCID 131717878HCID 131717878, compoundYield 76.8%

Procedure

By using 2.56 g of Boc-Ser(Bzl)-Thr(Bzl)-Glu-OBzl and 2.00 g of Boc-Gly-Ala-Ser(Bzl)-Leu-NHNH2, and the same procedure as in Reference Example 7 was repeated to obtain 3.13 g (yield: 76.8%) of the above-mentioned objective product.

Sources & evidence

ORD record: ord-f8040df8210c48a8a4dd324a70b0ee2d
Source dataset: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05204326

Reaction notes

Loading…