Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (2,6-Difluoropyridin-3-yl)boronic acid | HCID 2762713 | — |
| Reactant | HCID 178444243 | HCID 178444243 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178444284 | HCID 178444284 | — |
Reaction Steps
A mixture of 0,05 M of 4-(trans-4-pentylcyclohexyl)bromobenzene, 0,06 M of 2,6-difluoropyridine-3-boronic acid, 1,25 g of Pd(PPh3)4, 100 ml of toluene, 40 ml of ethanol and 50 ml of 2 M Na2CO3 -solution is heated at 60 ° C under stirring for 2 hours. Customary work-up and recrystallisation from ethanol gives 2,6-difluoro-3-[4-(trans-4-pentylcyclohexyl)phenyl]-pyridine with C 58° N 107° I.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05205962 |
|---|
| Source dataset | uspto-grants-1993_04 |
|---|
| ORD ID | ord-59343c2aff284eed88b74ce2cdf19ed3 |
|---|
| Source note | uspto-grants-1993_04 |
|---|
