Ethanol → 136535-21-2

HRID 1591036Notes

Reaction equation

HRID 1591036 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:9]=[CH:8][C:6]([OH:7])=[CH:5][C:4]=1[OH:10].[CH2:11](O)[CH3:12]>>[Cl:1][CH2:11][C:12]1[O:10][C:4]2[CH:5]=[C:6]([OH:7])[CH:8]=[CH:9][C:3]=2[N:2]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 134088224-Aminobenzene-1,3-diol hydrochloride

Product 1

HCID 19766032136535-21-2

Procedure

1.78 g (11.3 mmol) of said ethyl chloromethylimidate hydrochloride, 1.22 g (7.55 mmol) of 4-aminoresorcinol hydrochloride, and 20 ml of ethanol were introduced into a two-necked flask provided with a Dimroth condenser, and the mixture was refluxed with heat in argon atmosphere for a whole day and night. After completion of the reaction and cooling, the crystal was filtered and washed with hexane, then the object was vacuum dried. There was obtained 0.40 g (2.33 mmol) of 2-chloromethyl-6-hydroxybenzoxazole, and the yield of the reaction was 30.9%.

Workup

  1. customprovided with a Dimroth condenser
  2. temperaturethe mixture was refluxed
  3. temperaturewith heat in argon atmosphere for a whole day
  4. customAfter completion of the reaction
  5. temperaturecooling
  6. filtrationthe crystal was filtered
  7. washwashed with hexane
  8. customdried

Sources & evidence

ORD record
ord-4f36c14eca8f40098f01b43b4e09c15d
Source dataset
uspto-grants-1993_04
Patent number
US05206149

Reaction notes

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