反应详情

温度

0 °C

A mixture of 2-aminoethanethiol hydrochloride (31.0 g, 0.273 mol) and 140 mL of methanol is cooled to 0° C. and treated with pulverized sodium hydroxide (12.0 g, 0.475 mol) followed by trans-methyl 4-methoxycinnamate (52.4 g, 0.273 mol). The reaction mixture is allowed to warm to room temperature and stirred for 5 days. The mixture is then heated to 60° C. for 30 minutes and filtered while still warm. The methanolic solution is concentrated to ca 1/4 volume and the product is isolated by filtration (35 g).

1. temperatureto warm to room temperature
2. temperatureThe mixture is then heated to 60° C. for 30 minutes
3. filtrationfiltered
4. temperaturewhile still warm
5. concentrationThe methanolic solution is concentrated to ca 1/4 volume
6. customthe product is isolated by filtration (35 g)