HCID 12400364, compound → HCID 19766133, compound

Participants

Reaction Conditions

Reaction Steps

3,4-Dihydro-7-phenyl-1,4-thiazepin-5(2H)-one (3.30 g, 16.2 mm cl) is added to 50 mL of absolute diethyl ether. The reaction mixture is then cooled to 0° C. and lithium aluminum hydride (16.7 mL of a 1M ethereal solution) is added. The reaction mixture is then stirred overnight at room temperature and is quenched by the addition of 2.5 mL of water followed by 5 mL of 10% aqueous sodium hydroxide solution. The solids are filtered and washed with absolute ethanol. The filtrates are combined and concentrated under reduced pressure and the resulting residue is chromatographed on silica eluting with 10:1 dichloromethane:methanol to obtain 1.63 g of the product as a clear oil.

Provenance & Evidence