Dimethylamine → HCID 178483118, compound

Participants

Reaction Steps

In a method similar to Example 3, the product of Example 1, Step 2 (0.250 g, 0.572) was converted to the title compound with dimethylamine gas to give, after recrystallization from diethyl ether/hexane, 0.19 g (76%) of product as a white solid: mp 135°-140° C.; 1H NMR (DMSO-D6): δ 8.09 (br s, 1H), 7.23 (br s, 1H), 7.10 (d, 1H), 6.82 (d, 1H), 5.84 (br s, 1H), 4.77 (m, 1H), 3.75 (m, 1H), 3.35 (s, 3H), 2.53 (s, 3H), 1.38 (s, 3H), 1.19 (s, 3H); IR (KBr): 3400, 1600 cm-1 ; MS (m/z) 437 (MH+, 100%), 419 (65), 245 (35) 177 (70); [α]D25 = -85.4 (THF).

Provenance & Evidence