反应详情

In a method similar to Example 5, the product of Example 1, Step 2 (0.250 g, 0.572 mmol) was converted to the title compound with 4-(trifluoromethyl)benzylamine (0.09 mL, 0.629 mmol) to afford 0.25 g (77%) of product as a white solid: mp 283°-284° C.; 1H NMR (DMSO-D6): δ 8.94 (d, 1H), 8.92 (t, 1H), 7.78 (d, 2H), 7.64 (d, 2H), 7.32 (d, 1H), 7.21 (dd, 1H), 6.90 (d, 1H), 6.00 (d, 1H), 4.80 (t, 1H), 4.62 (d, 2H), 3.62 (m, 1H), 1.40 (s, 3H), 1.20 (s, 3H); IR (KBr) 3300, 1610 cm-1 ; MS (m/z) 567 (MH+, 100%); [α]D25 =-44.8 (THF).