HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroacetate → HCID 17990698, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroacetate | HCID 7751 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-(2-Hydroxyethyl)imidazole | HCID 74168 | — |
| Reactant | HCID 19766434 | HCID 19766434 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 17990698 | HCID 17990698 | — |
Reaction Steps
The 5-(imidazol-1-yl)-3-oxa-pentanoic acid-hydrochloride used as the starting material is prepared in the following manner: 1-(2-hydroxyethyl)imidazole (J. Chem. Soc. 1977, 1272) is reacted in the presence of sodium hydride with ethyl chloroacetate in dimethyl formamide to form 5-(imidazol-1-yl)-3-oxa-pentanoic acid-ethyl ester (oil) and the desired acid is obtained from it by heating with 6 N hydrochloric acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05206253 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-68a166e1c27947fb83d8bcbcf95403e9 |
| Source note | uspto-grants-1993_04 |