HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propylene Oxide → alpha(or beta)-methyl-1H-imidazole-1-ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propylene Oxide | HCID 6378 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 5-(Imidazol-1-yl)-4-methyl-3-oxa-pentanoic acid-hydrochloride | HCID 19766337 | — |
| Reactant | 1-Hydroxy-5-(imidazol-1-yl)-4-methyl-3-oxa-pentane-1,1-diphosphonic acid | HCID 19766394 | — |
| Product | alpha(or beta)-methyl-1H-imidazole-1-ethanol | HCID 109147 | — |
| Product | 5-(Imidazol-1-yl)-4-methyl-3-oxa-pentanoic acid-ethyl ester | HCID 17990705 | — |
Reaction Steps
The 5-(imidazol-1-yl)-4-methyl-3-oxa-pentanoic acid-hydrochloride used as the starting material was prepared in the following manner: reaction of the sodium salt of the imidazole with propene oxide yields the 2-(imidazol-1-yl)-1-propanol (b.p.0.1 : 147°-150° C.) from which the 5-(imidazol-1-yl)-4-methyl-3-oxa-pentanoic acid-ethyl ester (oil) is obtained by reaction with ethyl bromoacetate in dimethyl formamide in the presence of sodium hydride which is then saponified with 3N hydrochloric acid to form the desired acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05206253 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-b5100ed72aef45b9b741de2fb1877cdf |
| Source note | uspto-grants-1993_04 |