HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → methyl 2-(4-acetylphenoxymethyl)phenylglyoxylate O-methyloxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4'-Hydroxyacetophenone | HCID 7469 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate | HCID 54028047 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | methyl 2-(4-acetylphenoxymethyl)phenylglyoxylate O-methyloxime | HCID 54461346 | 78% |
Reaction Steps
3.0 g (0.022 mol) of 4-hydroxyacetophenone and 6.0 g (0.021 mol) of methyl 2-bromomethylphenylglyoxylate O-methyloxime are dissolved in 30 ml of dimethylformamide, and 5.5 g (0.040 mol) of potassium carbonate are added. The mixture is stirred at room temperature for 24 hours, hydrolyzed with water and extracted with methyl tert-butyl ether. The organic phase is washed with water, dried and concentrated. 5.3 g (78%) of methyl 2-(4-acetylphenoxymethyl)phenylglyoxylate O-methyloxime are obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05206266 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-1f31905fb4744d74a1fc9ab02f67e9b1 |
| Source note | uspto-grants-1993_04 |