4-Chlorophenyl Isocyanate → HCID 18940641, compound

Participants

Reaction Steps

1,3-Dihydro-3-amino-5-phenyl-2H-1,4-benzodiazepin-2-thione (1.5 mmole) and 4-chlorophenylisocyanate (1.5 mmole) were combined in 40 mL of dry tetrahydrofuran at 0° C. The reaction mixture was warmed to room temperature over a 1 hour period and diluted with 20 mL of tetrahydrofuran. The reaction mixture was filtered and concentrated under reduced pressure. The residual material was chromatographed on silica gel (96:4:0.4 chloroform-methanol-concentrated ammonium hydroxide) to give the title compound analytically pure after trituration with ether/petroleum ether: the 1HNMR spectrum is consistent with the structure of the title compound.

Provenance & Evidence