1-Bromo-3-chloropropane → 4-(4-Chlorobutyl)pyridine--hydrogen chloride (1/1)

Participants

Reaction Steps

The reaction of 4-picolyllithium and 3-bromo-1-chloropropane was exothermic. It was extremely critical to keep internal temperature less than -65° C. to avoid the reaction of the desired product with 4-picolyllithium to give 1,5-bis-(4-pyridinyl)-pentane. The addition took about 2 h.

Provenance & Evidence