Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Amino-4-ethoxythiophene-3-carbonitrile | HCID 13742380 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Pentanol | HCID 6276 | — |
| Product | HCID 13742382 | HCID 13742382 | — |
Reaction Steps
200 parts of formic acid are added dropwise to 500 parts of acetic anhydride at room temperature, and 168 parts of 2-amino-3-cyano-4-ethoxythiophene are introduced after 2 hours. The mixture is stirred for 4 hours at 50° C., after which 1000 parts of water are run into the hot mixture. The mixture is cooled and the product is then filtered off under suction, washed with water and dried. 174 parts of 2-formylamino-3-cyano-4-ethoxythiophene of melting point 191°-192° C. (from pentanol) are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05206375 |
|---|
| Source dataset | uspto-grants-1993_04 |
|---|
| ORD ID | ord-8a91f6767cb24a1ebf79699d8a5ea29b |
|---|
| Source note | uspto-grants-1993_04 |
|---|
