Water → HCID 13742384, compound

Participants

Reaction Steps

168 parts of 2-amino-3-amino-4-ethoxythiophene are dissolved in 500 parts by volume of dimethylformamide, 101 parts of triethylamine are added, and 130 parts of monochloroacetyl chloride are introduced dropwise at 50° C. Stirring is continued for 4 hours at 50° C., after which the reaction mixture is poured onto 2000 parts of water. The product is filtered off under suction, washed with water and dried, and 240 parts of 2-(2-chloroacetylamino)-3-cyano-4-ethoxythiophene are obtained. A sample recrystallized from acetic acid melts at 243°-244° C. and has a chlorine content of 14.1% (calculated: 14.5%).

Provenance & Evidence