Formic Acid → N-(4-Chloro-3-cyanothiophen-2-yl)formamide

HRID 1591287Notes

Reaction equation

HRID 1591287 reaction equation
CN(C)[CH:3]=[N:4][C:5]1[S:6][CH:7]=[C:8]([Cl:12])[C:9]=1[C:10]#[N:11].C(O)=[O:15]>O>[Cl:12][C:8]1[C:9]([C:10]#[N:11])=[C:5]([NH:4][CH:3]=[O:15])[S:6][CH:7]=1

Participants

4

Reactant 2

HCID 284Formic AcidHCID 54085961N'-(4-Chloro-3-cyanothiophen-2-yl)-N,N-dimethylmethanimidamide

Product 1

HCID 13742389N-(4-Chloro-3-cyanothiophen-2-yl)formamideYield 77%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4.5 parts of N,N-dimethyl-N'-(4-chloro-3-cyano-thien-2-yl)-formamidine in a mixture of 20 parts of formic acid and 20 parts of water are heated at the boil for 1 hour. After the mixture has cooled to room temperature, the product is filtered off under suction, washed with water and dried. 3 parts (77% of theory) of N-(4-chloro-3-cyanothien-2-yl)-formamide are obtained.

Workup

  1. temperatureare heated at the boil for 1 hour
  2. filtrationthe product is filtered off under suction
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-7cd97e806ad643448a047ffce40ccf91
Source dataset
uspto-grants-1993_04
Patent number
US05206375

Reaction notes

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