Benzenesulfinic acid, sodium salt → N,N-dimethyl-N'-(3-cyano-5-formyl-4-phenylsulfonylthien-2-yl)-formamidine

HRID 1591300Notes

Reaction equation

HRID 1591300 reaction equation
[CH3:1][N:2]([CH3:15])[CH:3]=[N:4][C:5]1[S:6][C:7]([CH:13]=[O:14])=[C:8](Cl)[C:9]=1[C:10]#[N:11].[C:16]1([S:22]([O-:24])=[O:23])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[Na+]>>[CH3:1][N:2]([CH3:15])[CH:3]=[N:4][C:5]1[S:6][C:7]([CH:13]=[O:14])=[C:8]([S:22]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:24])=[O:23])[C:9]=1[C:10]#[N:11]

Participants

3

Reactant 2

HCID 2723840Benzenesulfinic acid, sodium saltHCID 54382946N'-(4-chloro-3-cyano-5-formyl-2-thienyl)-N,N-dimethylformamidine

Product 1

HCID 54574268N,N-dimethyl-N'-(3-cyano-5-formyl-4-phenylsulfonylthien-2-yl)-formamidine

Procedure

A mixture of 12.1 parts of N,N-dimethyl-N'-(4-chloro-3-cyano-5-formylthien-2-yl)-formamidine, 8.2 parts of sodium phenylsulfinate and 70 parts of methylglycol is heated at the boil for 1 hour. The precipitated product is then filtered off under suction when the mixture is cold and is washed with methylglycol and then with water and dried. 9.7 parts of N,N-dimethyl-N'-(3-cyano-5-formyl-4-phenylsulfonylthien-2-yl)-formamidine are obtained.

Workup

  1. temperatureis heated at the boil for 1 hour
  2. filtrationThe precipitated product is then filtered off under suction when the mixture
  3. washis washed with methylglycol
  4. dry with materialwith water and dried

Sources & evidence

ORD record
ord-9bceb34f17b14ca78411d999c5e1eeb8
Source dataset
uspto-grants-1993_04
Patent number
US05206375

Reaction notes

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