反应详情

A solution of 82 parts of sodium phenylsulfinate in 500 parts of water is added to a mixture of 93.3 g of 2-amino-4-chloro-3-cyano-5-formylthiophene an 500 parts of methylglycol, and the reaction mixture is heated at the boil for 6 hours. Thereafter, the solution is filtered while hot and the filtrate is left to stand overnight. The precipitated product is then filtered off under suction, washed with water and dried. 121 parts (83% of theory) of 2-amino-3-cyano-5-formyl-4-phenylsulfonylthiophene are obtained.

1. temperaturethe reaction mixture is heated at the boil for 6 hours
2. filtrationThereafter, the solution is filtered while hot and the filtrate
3. waitis left
4. filtrationThe precipitated product is then filtered off under suction
5. washwashed with water
6. customdried