HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 2-(2,4-Difluorophenyl)-3-methyl-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone | HCID 588080 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 4-Isopropylpyrimidine | HCID 18956506 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(2,4-Difluorophenyl)-3-methyl-3-(pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol | HCID 18956517 | 2.7% |
Reaction Steps
Treatment of the product of part (i) (2.46 g) with lithium diisopropylamide (0.02 mole) in dry tetrahydrofuran followed by 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone (4.49 g) according to the method of Example 3 gave the title compound, (0.185 g), m.p. 126°-127° (from ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05206364 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-b25ed6b121134417bb5dce255923c8c9 |
| Source note | uspto-grants-1993_04 |