Formic Acid → HCID 19766996, compound

Participants

Reaction Steps

47 g of 1,3-diaminobenzene-4-sulfonic acid in 215 ml of water and 35 g of formic acid were heated under reflux for 3 hours. The pH was then adjusted to 6.5 with caustic soda solution and, at 20° C., 35 g of acetic anhydride were added dropwise, while the pH was kept between 6.0 and 7.0 with caustic soda solution. After 1 hour, the pH was adjusted to 4.0 with hydrochloric acid, and 200 g of sodium chloride were added. Stirring was continued for 5 hours, after which the precipitated 1-(N-acetylamino)-3-(N-formylamino)benzene-4-sulfonic acid was isolated by filtration.

Provenance & Evidence