Hydrochloric Acid → HCID 14876106, compound

Participants

Reaction Conditions

Reaction Steps

220 g of 3-(N-formylamino)aniline-4-sulfonic acid in 1,500 ml of water were reacted with 140 g of acetic anhydride at a pH of 5.0 to 5.5. The mixture was heated, at pH 7.0, to 50° C., and 200 g of diethyl sulfate were added. The pH was then adjusted to 12.5 to 13.0 with caustic soda solution and stirring was continued for 2 hours. The pH was then adjusted to -0.5 to 0 with hydrochloric acid, and the mixture was boiled under reflux at 100° C. for 3 hours. After cooling, it was adjusted to pH 1.0 with caustic soda solution, and 200 g of sodium chloride were added. The precipitated 3-(N-ethylamino)aniline-4-sulfonic acid was then isolated by filtration in vacuo.

Provenance & Evidence