HCID 18651488, compound → HCID 178453551, compound

Participants

Reaction Steps

The intermediate obtained in Step B (150 mg, 0.18 mmol) dissolved in 5 mL methanol was hydrogenated over 30 mg of Pd(OH)2 on carbon at one atmosphere for 2 hours. The mixture was filtered through Celite and the filtrate concentrated under vacuum. The residue was purified by medium pressure liquid chromatography on silica, eluting with ethyl acetate/acetonitrile/methanol (9:1:1) to afford 62 mg (0.11 mmol, 59%) of the product as a colorless glass. 1H NMR (200 MHz, CD3OD): 1.39 (s,9H), 2.0-2.5 (m,6H), 3.26 (t,7 Hz,2H), 4.31 (dd;7,12 Hz;1H), 4.83 (d,16 Hz,1H), 5.20 (d,16 Hz,1H), 6.98 (d,8 Hz,2H), 7.1-7.6 (m,10H). FAB-MS: calc. for C32H35N7O4 581; found 582 (M+H,19%).

Provenance & Evidence