HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one → 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one | HCID 4434433 | — |
| Reactant | 3-(((Benzyloxy)carbonyl)amino)-3-methylbutanoic acid | HCID 14551007 | — |
| Product | 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide | HCID 21836609 | — |
Reaction Steps
Prepared from 3-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (Example 1, Step A) and 3-benzyloxycarbonylamino-3-methylbutanoic acid (Example 1, Step E) by the procedure described in Example 1, Step F. 1H NMR (200 MHz, CDCl3): 1.38 (s,3H), 1.39 (s,3H), 1.82 (m,1H), 2.52 (s,2H), 2.5-3.0 (m,3H), 4.51 (m,1H), 5.07 (br s,2H), 5.58 (br s,1H), 6.68 (d,7 Hz,1H), 6.96 (d,8 Hz,1H), 7.1-7.4 (m,8H), 7.62 (br s,1H). FAB-MS: calculated for C23H27N3O4 409; found 410 (M+H,100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05206235 |
| Source dataset | uspto-grants-1993_04 |
| ORD ID | ord-59a62302b6ed4b579d834808d7e474b9 |
| Source note | uspto-grants-1993_04 |