N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine → 2-t-Butoxycarbonylamino-2-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]propanamide

Participants

Role	Name	HCID	Charge
Reactant	N-((1,1-dimethylethoxy)carbonyl)-2-methyl-alanine	HCID 2733845	—
Reactant	(R)-3-amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one	HCID 10103689	—
Product	2-t-Butoxycarbonylamino-2-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]propanamide	HCID 10808566	—

Reaction Steps

Prepared from 2-(t-butoxycarbonylamino)-2-methylpropanoic acid and 3(R)-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (Example 1, Step B) by the procedure described in Example 1, Step F. 1H NMR (200 MHz, CDCl3): 1.42 (s,12H), 1.46 (s,3H), 1.90 (m,1H), 2.5-3.0 (m,3H), 4.48 (m,1H), 5.01 (br s,1H), 6.97 (d,8 Hz,1H), 7.1-7.3 (m,3H), 7.9 (br s,1H). FAB-MS: calculated for C19H27N3O4 361; found 362 (M+H,30%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05206235
Source dataset	uspto-grants-1993_04
ORD ID	ord-af88ec4d36714f67a3fb918c2adcb6b1
Source note	uspto-grants-1993_04