(R)-3-amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one → 3-(Benzyloxycarbonylamino)-2,2-dimethyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-propanamide

Participants

Role	Name	HCID	Charge
Reactant	(R)-3-amino-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one	HCID 10103689	—
Reactant	3-(((Benzyloxy)carbonyl)amino)-2,2-dimethylpropanoic acid	HCID 14551010	—
Product	3-(Benzyloxycarbonylamino)-2,2-dimethyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-propanamide	HCID 18651458	—

Reaction Steps

Prepared from 3-(benzyloxycarbonylamino)-2,2-dimethylpropanoic acid and 3(R)-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (Example 1, Step B) by the procedure described in Example 1, Step F. 1H NMR (200 MHz, CDCl3): 1.19 (s,6H), 1.90 (m,1H), 2.6-3.0 (m,3H), 3.26 (d,6 Hz,2H), 4.46 (m,1H), 5.07 (s,2H), 5.7 (br t,1H), 6.62 (d,7 Hz,1H), 6.97 (d,8 Hz,1H), 7.1-7.3 (m,3H), 7.3 (s,5H), 8.14 (br s,1H). FAB-MS: calculated for C23H27N3O4 409; found 410 (M+H,100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05206235
Source dataset	uspto-grants-1993_04
ORD ID	ord-c2a9291e477b4638ac7d025fca47b47f
Source note	uspto-grants-1993_04