3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide → HCID 57119785, compound

HRID 1591486Notes

Reaction equation

HRID 1591486 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=2)=[CH:5][CH:4]=1.[C:25]([O:29][C:30]([NH:32][C:33]([CH3:51])([CH3:50])[CH2:34][C:35]([NH:37][C@@H:38]1[CH2:44][CH2:43][C:42]2[CH:45]=[CH:46][CH:47]=[CH:48][C:41]=2[NH:40][C:39]1=[O:49])=[O:36])=[O:31])([CH3:28])([CH3:27])[CH3:26]>>[N+:22]([C:19]1[CH:20]=[CH:21][C:16]([O:15][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:6]2[CH:7]=[CH:8][C:3]([CH2:2][N:40]3[C:41]4[CH:48]=[CH:47][CH:46]=[CH:45][C:42]=4[CH2:43][CH2:44][C@@H:38]([NH:37][C:35](=[O:36])[CH2:34][C:33]([NH:32][C:30](=[O:31])[O:29][C:25]([CH3:27])([CH3:26])[CH3:28])([CH3:50])[CH3:51])[C:39]3=[O:49])=[CH:4][CH:5]=2)=[CH:17][CH:18]=1)([O-:24])=[O:23]

Participants

3

Reactant 2

HCID 104746043-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamideHCID 21836591HCID 21836591, compound

Product 1

HCID 57119785HCID 57119785, compound

Procedure

Prepared from 4'-bromomethyl-2-(4-nitrophenoxy)-1,1'-biphenyl and 3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-(R)-yl]-butanamide (Example 57, Step A) by the procedure described in Example 69, Step D. 1H NMR (200 MHz,CDCl3): 1.32 (s,6H), 1.38 (s,9H), 1.78 (m,1H), 2.3-2.7 (m,5H), 4.47 (m,1H), 4.75 (d,15 Hz,1H), 5.13 (d,15 Hz,1H), 6.63 (d,7 Hz,1H), 6.75 (d,8 Hz,2H), 7.05-7.50 (m,/11H), 7.97 (s,1H), 7.98 (d,8 Hz,2H).

Sources & evidence

ORD record
ord-2322901e232044b8a93411f6d2342582
Source dataset
uspto-grants-1993_04
Patent number
US05206235

Reaction notes

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