3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide → 3-[[1-[[3-Bromo-2'-cyano-[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-benza zepin-3(R)yl]amino]-1,1-dimethyl-3-oxo-propylcarbamic acid, 1,1-dimethylethyl ester

Participants

Reaction Steps

Prepared from 3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide (Example 57, Step A) and 3'-bromo-4'-bromomethyl-1,1'-biphenyl-2-nitrile by the procedure described in Example 69, Step D. 1H NMR (200 MHz,CDCl3): 1.33 (s,3H), 1.34 (s,3H), 1.40 (s,9H), 1.91 (m,1H), 2.43 (d,14 Hz,1H), 2.55 (d,14 Hz,1H), 2.55-2.90 (m,3H), 4.62 (m,1H), 4.95 (d,16 Hz,1H), 5.28 (s,1H), 5.34 (d,16 Hz,1H), 6.63 (d,7 Hz,1H), 7.10-7.25 (m,4H), 7.45 (m,4H), 7.64 (m,1H), 7.75 (m,2H). FAB-MS (Li spike): calculated for C34H37BrN4O4 644, 646; found 651 (13%); 653 (15%).

Provenance & Evidence