反应详情

Prepared from 3-benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide (Example 51, Step A) and 4'-bromomethyl-2-trifluoromethyl-1,1'-biphenyl by the procedure described in Example 1, Step K. 1H NMR (300 MHz,CDCl3): 1.37 (s,3H), 1.39 (s,3H), 1.73 (m,1H), 2.2-2.6 (m,5H), 4.50 (m,1H), 4.82 (d,15 Hz,1H), 5.06 (s,2H), 5.29 (d,15 Hz,1H), 5.65 (s,1H), 6.70 (d,7 Hz,1H), 7.1-7.4 (m,14H), 7.44 (t,8 Hz,1H), 7.52 (t,8 Hz,1H), 7.71 (d,8 Hz,1H). FAB-MS: calculated for C37H36F3N3O4 643; found 644 (M+H,55%).