Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Venlafaxine | HCID 5656 | — |
| Reactant | 1-Dodecanethiol | HCID 8195 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Product | Desvenlafaxine | HCID 125017 | — |
Reaction Steps
Dodecanethiol (69 g), venlafaxine (55 g), and an ethanolic solution of sodium ethanolate (21%, 82 g) are charged to a pressure vessel. The temperature is raised to 150° C. and the reaction mixture is stirred for 2 days. Then the temperature is lowered and the solution is filtered. The pH of the filtrate is adjusted to 9.5 with aqueous hydrogen chloride. The crystals are collected by suction filtration. The cake is washed with ethanol and dried in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07291347B2 |
|---|
| Source dataset | uspto-grants-2007_11 |
|---|
| ORD ID | ord-a499a1fdf1094341abcdb9ac171d11fb |
|---|
| Source note | uspto-grants-2007_11 |
|---|
